Week 11 of the NFL season culminates with a terrific NFC matchup when the San Francisco 49ers meet the Arizona Cardinals at Estadio Azteka Stadium in Mexico City, Mexico.
This matchup has a 43-point total, but that doesn’t mean we don’t have some tremendous opportunities for prop bet success. Will 49ers wide receiver Deebo Samuel make an impact, or could Cardinals running back James Conner have another big game?
Find out in our NFL prop picks for 49ers vs. Cardinals on November 21.
You can also read our 49ers vs. Cardinals picks and predictions in addition to our best Jimmy Garoppolo player prop picks.
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